Impeding Migration and APC Conjugation Depolarization via ERM Proteins, Thereby Glucocorticoids Induce Effector T Cell
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چکیده
منابع مشابه
Glucocorticoids induce effector T cell depolarization via ERM proteins, thereby impeding migration and APC conjugation.
Glucocorticoids (GCs) repress lymphocyte function by controlling gene expression. In this study, we investigated Ag-specific effector T cells and provide evidence that GCs also modulate these cells' cytoskeletal architecture by nongenomic mechanisms. Following GC treatment, effector T cells rapidly lose their polarized morphology, which impedes both their migratory capacity and their interactio...
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Members of the ezrin-radixin-moesin (ERM) family of proteins are involved in multiple aspects of cell migration by acting both as crosslinkers between the membrane, receptors and the actin cytoskeleton, and as regulators of signalling molecules that are implicated in cell adhesion, cell polarity and migration. Increasing evidence suggests that the regulation of cell signalling and the cytoskele...
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